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Updated: Dec 15, 2025

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
Published on: July 6, 2022
Extrusions do not affect degenerative morphologic changes in lateral meniscus allografts during midterm follow-ups
Dong-Wook Son1, Seong-Il Bin2, Jong-Min Kim3
1Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Degenerative changes occurred in meniscus allografts after lateral transplantation, with decreased width and increased signal intensity observed. Graft extrusion did not significantly impact these meniscal changes or patient outcomes.
Area of Science:
- Orthopedic Surgery
- Biomedical Engineering
- Radiology
Background:
- Meniscus allograft transplantation (MAT) is a common procedure for knee injuries.
- Assessing graft integrity and degenerative changes is crucial for long-term outcomes.
- Graft extrusion is a potential complication that may influence graft degeneration.
Purpose of the Study:
- To investigate degenerative morphological changes in meniscus allografts after lateral MAT.
- To evaluate the influence of graft extrusion on these degenerative changes.
Main Methods:
- Retrospective analysis of 91 patients undergoing lateral MAT.
- Serial MRI scans evaluated at 6 weeks, 1 year, and midterm (3-7 years) follow-up.
- Comparison of meniscal width, thickness, and intrameniscal signal intensity (IMSI) between extruded and non-extruded groups.
Main Results:
- Overall mid-body meniscus width decreased (p<0.01) and IMSI increased (p<0.01) during midterm follow-ups.
- No significant differences in meniscal width, thickness, or IMSI were found between extruded and non-extruded groups at midterm.
- Incidence of meniscus tears and Lysholm scores did not differ significantly between groups.
Conclusions:
- Lateral MAT leads to degenerative changes in the meniscus allograft, characterized by decreased width and increased IMSI at the mid-body.
- Meniscal allograft extrusion does not appear to influence postoperative degenerative changes in width, thickness, or IMSI.
- Graft extrusion did not significantly affect meniscal tear incidence or functional outcomes (Lysholm scores).
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