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Role of the DEK oncogene in the development of squamous cell carcinoma

Kazuhisa Ishida1,2, Takayuki Nakashima1,2, Toshiyuki Shibata2

  • 1Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

International Journal of Clinical Oncology
|July 14, 2020
PubMed

Insights

The DEK oncogene, a nuclear factor, is implicated in various cancers, including squamous cell carcinoma (SCC). Understanding DEK

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • DEK is a conserved nuclear factor involved in cellular processes.
  • DEK functions as an oncogene, notably in acute myeloid leukemia and various cancers.
  • DEK overexpression is linked to squamous cell carcinoma (SCC) progression and diagnosis.

Purpose of the Study:

  • To review the role of the human DEK oncogene in SCC.
  • To highlight DEK as a potential therapeutic target for HPV-associated SCC.

Main Methods:

  • Literature review of studies on DEK and SCC.
  • Analysis of DEK's function in cancer progression.

Main Results:

  • DEK plays significant roles in both early and late stages of SCC.
  • DEK is a potential biomarker for early SCC diagnosis.
  • DEK is a promising therapeutic target for HPV-associated SCC.

Conclusions:

  • DEK oncogene is critically involved in SCC pathogenesis.
  • Further research is needed to elucidate DEK's precise mechanisms in SCC.
  • Targeting DEK may offer new therapeutic strategies for SCC.
Keywords:
DEKOncogeneSquamous cell carcinoma

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