Emicizumab treatment and monitoring in a paediatric cohort: real-world data

Assaf A Barg1,2, Tami Livnat1,2, Ivan Budnik3

  • 1National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel.

Insights

Emicizumab prophylaxis is safe and effective for severe haemophilia A in children, with zero bleeds in half of patients. However, laboratory monitoring, including thrombin generation, cannot predict trauma-related bleeding risk.

Area of Science:

  • Paediatric Haematology
  • Pharmacology
  • Clinical Trials

Background:

  • Limited real-world data exists on emicizumab use in paediatric severe haemophilia A (HA).
  • Evaluating safety, efficacy, and monitoring is crucial for this population, including infants and non-inhibitor patients.

Purpose of the Study:

  • To assess the safety, efficacy, and laboratory monitoring parameters of emicizumab prophylaxis in children with severe HA.
  • To investigate bleeding risk, adverse events, and surgical outcomes in this cohort.

Main Methods:

  • A cohort of 40 children with severe HA received emicizumab prophylaxis.
  • Data collected included bleeding events, trauma, adverse events, surgeries, emicizumab levels, aPTT, and thrombin generation.
  • Median follow-up was 45 weeks.

Main Results:

  • Twenty patients experienced zero bleeds; all bleeds were trauma-related.
  • Sixteen surgical interventions in 12 patients showed no thrombotic complications.
  • Prolonged aPTT normalized with emicizumab, correlating with its plasma levels. Thrombin generation increased, but was lower in younger infants.

Conclusions:

  • Emicizumab prophylaxis is safe and well-tolerated in paediatric severe HA.
  • Laboratory monitoring, including thrombin generation, did not predict bleeding risk in this study.
  • Further research is needed for surgical procedures, but routine thrombin generation monitoring is not supported.

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