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Responses of human B-cells to recombinant lymphokines
G Gallagher1, N Taylor, J Willdridge
1Immunology Division, University of Strathclyde, Todd Centre, Glasgow.
Developments in Biological Standardization
|January 1, 1988
Abstract:
The effects of recombinant or purified cytokines on the growth and differentiation of human B-cells from a variety of sources were evaluated. The results suggest that IL-1, BCGF and BSF-2 have either "growth-factor" or "differentiation-factor" activity and that only IL-2 has both these functions. In addition, evidence is presented that the two forms of human IL-1 affect B-cell growth differently. Finally, the separation of human normal and leukaemic B-cells into subsets defined by their buoyant cell density, is described.