Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated multi-omic profiling reveals two distinct splenic marginal zone lymphoma subgroups with prognostic relevance.

Blood advances·2026

Same author

Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

Blood·2026

Same author

GLYATL1 is associated with metabolic and epigenetic changes and with endocrine resistance in luminal breast cancer.

Clinical epigenetics·2026

Same author

Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor.

Nature communications·2026

Same author

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition.

International journal of cancer·2026

Same author

Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD.

EMBO molecular medicine·2026

Same journal

Nucleic acid-based therapeutic strategies for modulator-refractory cystic fibrosis-causing variants.

Human molecular genetics·2026

Same journal

Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.

Human molecular genetics·2026

Same journal

Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.

Human molecular genetics·2026

Same journal

Retraction: Aqua-soluble DDQ reduces the levels of Dr1 and Ab and inhibits abnormal interactions between Ab and Dr1 and protects Alzheimer's disease neurons from Ab- and Dr1-induced mitochondrial and synaptic toxicities.

Human molecular genetics·2026

Same journal

Retraction: Breast cancer cell-derived exosome-delivered microRNA-155 targets UBQLN1 in adipocytes and facilitates cancer cachexia-related fat loss.

Human molecular genetics·2026

Same journal

Editor's Note: Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease.

Human molecular genetics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 15, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Molecular tumor classification using DNA methylome analysis.

Martin Sill^1,2, Christoph Plass³, Stefan M Pfister^1,2,4

¹Hopp Children's Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany.

Human Molecular Genetics

|July 14, 2020

Summary

This summary is machine-generated.

DNA methylation analysis offers a stable and specific method for developing reliable tumor classifiers. This review highlights its impact on cancer classification, discovering new subtypes, and patient stratification, especially for brain tumors, sarcomas, and blood cancers.

More Related Videos

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Related Experiment Videos

Last Updated: Dec 15, 2025

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Area of Science:

Molecular Oncology
Epigenetics
Cancer Genomics

Background:

Tumor classification traditionally relies on histopathology and genetics, but molecular patterns offer enhanced precision.
DNA methylation patterns are highly specific to tissue and cell types and are exceptionally stable, making them ideal biomarkers.
Existing DNA methylome analysis-based tumor classifiers are emerging as powerful tools in oncology.

Purpose of the Study:

To review current tumor classifiers that utilize DNA methylome analysis.
To provide an overview of the impact of these classifiers on cancer classification, identification of novel cancer subentities, and patient stratification.
To focus on the application of DNA methylation analysis in brain tumors, sarcomas, and hematopoietic malignancies.

Main Methods:

Comprehensive literature review of studies employing DNA methylome analysis for tumor classification.
Analysis of the performance and applications of existing DNA methylation-based tumor classifiers.
Discussion of the integration of DNA methylome analysis with traditional diagnostic methods.

Main Results:

DNA methylome analysis enables the development of robust tumor classifiers with high accuracy.
These classifiers are instrumental in refining cancer classification, identifying previously unknown cancer subtypes, and enabling precise patient stratification.
Significant progress has been made in applying these techniques to diverse malignancies, including brain tumors, sarcomas, and hematopoietic malignancies.

Conclusions:

DNA methylome analysis represents a significant advancement in cancer diagnostics, complementing histopathological and genetic approaches.
The potential for epigenomic analysis in liquid biopsies opens new avenues for non-invasive cancer detection and monitoring.
Continued development and application of DNA methylation classifiers promise to revolutionize cancer diagnosis and treatment strategies.