Related Experiment Video
Updated: Dec 15, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
SARS-CoV-2; What We Know so far
Huda Fatima Rajani1, Fatima Ahmed Alshaikh2, Amir Anushiravani3
1Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a rapidly spreading respiratory tract infection. Current diagnostics include PCR and radiography, with no definitive treatment available, though antivirals are in trials.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019.
- The virus has caused a global pandemic, affecting over 1.1 million individuals by April 5, 2020.
- SARS-CoV-2 is zoonotic in origin, believed to be derived from bats, and causes respiratory tract infections.
Purpose of the Study:
- To provide an overview of the SARS-CoV-2 outbreak.
- To highlight diagnostic methods and public health recommendations.
- To discuss the current status of treatment options.
Main Methods:
- Review of available scientific literature and public health reports.
- Identification of key diagnostic tools: real-time polymerase chain reaction (PCR) and radiography.
- Adherence to guidelines from the Center for Disease Control and Prevention (CDC) and World Health Organization (WHO).
Main Results:
- SARS-CoV-2 is a highly contagious virus responsible for a severe respiratory illness.
- Early detection relies on molecular (real-time PCR) and imaging (radiography) techniques.
- No specific antiviral treatment is currently approved, but clinical trials are ongoing.
Conclusions:
- Effective management of the SARS-CoV-2 pandemic requires strict adherence to public health guidelines.
- Continued research into antiviral therapies is crucial for developing effective treatments.
- Early diagnosis and implementation of precautionary measures are vital for controlling the spread.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Viral Mutations

