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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Conjugated Proteins02:50

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Updated: Dec 15, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2; What We Know so far.

Huda Fatima Rajani1, Fatima Ahmed Alshaikh2, Amir Anushiravani3

  • 1Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Archives of Iranian Medicine
|July 14, 2020
PubMed
Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a rapidly spreading respiratory tract infection. Current diagnostics include PCR and radiography, with no definitive treatment available, though antivirals are in trials.

Keywords:
Antiviral agentsRadiographyReal-time polymerase chain reactionSARS-CoV-2

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Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019.
  • The virus has caused a global pandemic, affecting over 1.1 million individuals by April 5, 2020.
  • SARS-CoV-2 is zoonotic in origin, believed to be derived from bats, and causes respiratory tract infections.

Purpose of the Study:

  • To provide an overview of the SARS-CoV-2 outbreak.
  • To highlight diagnostic methods and public health recommendations.
  • To discuss the current status of treatment options.

Main Methods:

  • Review of available scientific literature and public health reports.
  • Identification of key diagnostic tools: real-time polymerase chain reaction (PCR) and radiography.
  • Adherence to guidelines from the Center for Disease Control and Prevention (CDC) and World Health Organization (WHO).

Main Results:

  • SARS-CoV-2 is a highly contagious virus responsible for a severe respiratory illness.
  • Early detection relies on molecular (real-time PCR) and imaging (radiography) techniques.
  • No specific antiviral treatment is currently approved, but clinical trials are ongoing.

Conclusions:

  • Effective management of the SARS-CoV-2 pandemic requires strict adherence to public health guidelines.
  • Continued research into antiviral therapies is crucial for developing effective treatments.
  • Early diagnosis and implementation of precautionary measures are vital for controlling the spread.