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The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19

Cássia L Braga1, Rodrigo P Silva-Aguiar2, Denise Battaglini3

  • 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Pharmacology Research & Perspectives
|July 14, 2020
PubMed

Insights

Understanding coronavirus disease 2019 (COVID-19) pathogenesis is crucial due to high fatality rates and lack of treatments. This review explores COVID-19 pathways and therapeutic targets, emphasizing the renin-angiotensin-aldosterone system.

Area of Science:

  • Virology
  • Immunology
  • Cardiovascular Research

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, presents a global health crisis with significant mortality.
  • The lack of specific vaccines and therapeutics underscores the urgent need to understand COVID-19 pathogenesis.
  • Unique characteristics of SARS-CoV-2 pose challenges for clinical management compared to SARS-CoV.

Purpose of the Study:

  • To elucidate the complex mechanisms underlying COVID-19 infection and pathogenesis.
  • To identify potential therapeutic targets for COVID-19 treatment.
  • To highlight the critical role of the renin-angiotensin-aldosterone system in COVID-19.

Main Methods:

  • Review of existing literature on SARS-CoV-2, COVID-19, and the renin-angiotensin-aldosterone system.
  • Analysis of proposed molecular pathways involved in viral entry and replication.
  • Examination of the interplay between SARS-CoV-2 and host cellular machinery.

Main Results:

  • COVID-19 pathogenesis involves intricate interactions between the virus and host systems.
  • The renin-angiotensin-aldosterone system is implicated as a key player in disease progression.
  • Specific viral proteins and host factors are identified as potential therapeutic targets.

Conclusions:

  • A comprehensive understanding of COVID-19 pathogenesis is essential for developing effective treatments.
  • Targeting the renin-angiotensin-aldosterone system may offer a promising therapeutic strategy.
  • Further research into viral-host interactions can accelerate the development of novel interventions for COVID-19.

Keywords:
COVID-19SARS-CoV-2angiotensin-converting enzymeinflammationtherapy

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