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Postischemic Administration of IL-1α Neutralizing Antibody Reduces Brain Damage and Neurological Deficit in

Luca Liberale1,2, Nicole R Bonetti1,3, Yustina M Puspitasari1

  • 1Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland (L.L, N.R.B., Y.M.P., L.S., A.A., J.H.B., T.F.L., G.G.C.).

Circulation
|July 14, 2020
PubMed
Abstract

No abstract available in PubMed .

Keywords:
blood brain barriercerebrovascular diseaseinflammationinterleukin-1αinterleukinsneuroprotective agentsstroke

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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