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Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Related Experiment Video

Updated: Dec 15, 2025

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
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COVID-19: Review and hematologic impact.

Sílvia Letícia de Oliveira Toledo1, Leilismara Sousa Nogueira1, Maria das Graças Carvalho2

  • 1Universidade Federal de São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 14, 2020
PubMed
Summary

Routine hematological tests can quickly and affordably signal the need for specific SARS-CoV-2 testing. These blood tests also aid in predicting COVID-19 prognosis and managing patient care.

Keywords:
COVID-19Clinical featuresLaboratory findingsSARS-CoV-2

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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

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Area of Science:

  • Virology
  • Hematology
  • Public Health

Background:

  • Coronaviruses, including SARS-CoV-2, pose significant global health risks.
  • COVID-19 presents with nonspecific initial symptoms, complicating early diagnosis.
  • Hematological tests offer a practical, economical approach to identify potential SARS-CoV-2 infections.

Purpose of the Study:

  • To review the history, epidemiology, and pathophysiology of SARS-CoV-2.
  • To emphasize the role of laboratory diagnosis in COVID-19 management.
  • To highlight hematological changes associated with SARS-CoV-2 infection.

Main Methods:

  • Literature review on coronaviruses and SARS-CoV-2.
  • Analysis of epidemiological data and pathophysiology of COVID-19.
  • Focus on hematological parameters in COVID-19 patients.

Main Results:

  • Hematological abnormalities can indicate the need for specific SARS-CoV-2 diagnostic tests.
  • These findings assist in disease prognosis and clinical monitoring.
  • The review synthesizes information on virus history, epidemiology, and COVID-19's lab diagnosis.

Conclusions:

  • Hematological testing is a valuable tool for early COVID-19 detection and management.
  • Abnormal blood test results can guide further diagnostic workups.
  • Understanding hematological changes is crucial for optimizing patient care during the pandemic.