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High-Dose 8% Capsaicin Patch in Treatment of Chemotherapy-Induced Peripheral Neuropathy. A Systematic Review
Luis Cabezón-Gutiérrez1, Sara Custodio-Cabello1, Magda Palka-Kotlowska1
1Medical Oncology, Hospital Universitario de Torrejón, Madrid, Spain.
Introduction:
This is a review of the evidence from studies of the efficacy and tolerability of topically applied and high-concentration (8%) capsaicin in chemotherapy-induced peripheral neuropathy.
Methods:
For this review, we searched EMBASE and MEDLINE to June 20, 2020. The terms used in the search included capsaicin, capsaicin 8% patch, chemotherapy-induced peripheral neuropathy, and cancer.
Results:
A total of 98 studies were obtained, but only five were selected for the final analysis, with a total of 95 patients included. Three of the studies are prospective and two retrospective, including less than 30 patients per study. Capsaicin 8% patch provides significant pain relief in chemotherapy-induced peripheral neuropathy in all of them. However, the small number of studies (and patients) evaluated require caution with these results.
Conclusion:
Additional clinical trials are required to establish the definitive role of the capsaicin patch in the future.
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