Lignin-Based Spherical Structures and Their Use for Improvement of Cilazapril Stability in Solid State

Area of Science:

• Materials Science
• Biotechnology
• Pharmaceutical Science

Background:

• Biopolymer-based spherical particles offer unique properties like controlled size and surface functionality.
• These characteristics make them suitable for diverse scientific and industrial applications.
• Lignin, a renewable biopolymer, presents an opportunity for sustainable material development.

Purpose of the Study:

• To synthesize lignin-based spherical particles using hexadecyl(trimethyl)ammonium bromide (CTAB).
• To optimize particle preparation by varying biopolymer-surfactant ratios and experimental conditions.
• To evaluate the potential of these particles in improving drug molecule stability, specifically cilazapril (CIL).

Main Methods:

• Systematic variation of lignin and CTAB ratios, filtration, and reaction times.
• Morphological and dispersion analysis to characterize particle properties.
• Assessment of cilazapril stability when formulated with the optimized lignin particles (CIL@LC-2a 1:1 wt./wt.) under elevated temperature and humidity.

Main Results:

• Successfully prepared lignin spherical particles in micro- and nanosizes with desirable morphology.
• Identified an optimal formulation (CIL@LC-2a 1:1 wt./wt.) with superior physicochemical properties.
• Demonstrated significant improvement in cilazapril stability when protected by the lignin particles.

Conclusions:

• Lignin spherical particles can be effectively synthesized using CTAB.
• The developed lignin particles show excellent potential for stabilizing active pharmaceutical ingredients.
• These particles represent a promising biomaterial for shielding compounds from degradation.