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Published on: March 14, 2019
A meta-analysis comparing regorafenib with TAS-102 for treating refractory metastatic colorectal cancer
Guan-Li Su1, Yuan-Yuan Wang2, Jin-Cheng Wang1
1Department of Psychiatry and Psychotherapy, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Objective:
We performed this meta-analysis to compare the efficacy and toxicity of regorafenib and TAS-102.
Methods:
Electronic databases were searched to identify studies comparing the efficacy and safety of regorafenib and TAS-102 in patients with chemotherapy-refractory metastatic colorectal cancer using pooled analyses.
Results:
Three clinical trials were included in this analysis. Regarding the reasons for treatment discontinuation, regorafenib was significantly associated with disease progression (odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.21-0.50) and adverse events (OR = 4.38, 95% CI = 2.69-7.13). However, overall (OR = 0.97, 95% CI = 0.81-1.17) and progression-free survival (OR = 1.01, 95% CI = 0.86-1.18) did not significantly differ between the groups. The most common treatment-related adverse events in the regorafenib group were neutropenia (OR = 0.06, 95% CI = 0.03-0.11), hand-foot syndrome (OR = 50.34, 95% CI = 10.44-242.84), and liver dysfunction (OR = 34.51, 95% CI = 8.30-143.43). Conversely, the incidence of thrombocytopenia did not differ between the two groups.
Conclusions:
Regorafenib and TAS-102 have similar efficacy but different adverse event profiles. Differences in the toxicity profiles of the two drugs will help guide treatment selection.
