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Bacterial Quorum Sensing During Infection.

Sheyda Azimi1,2, Alexander D Klementiev1,2, Marvin Whiteley1,2,3

  • 1School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA; email: marvin.whiteley@biosci.gatech.edu, stephen.diggle@biosci.gatech.edu.

Annual Review of Microbiology
|July 15, 2020
PubMed
Summary
This summary is machine-generated.

Quorum sensing (QS) is a bacterial communication system crucial for virulence. Understanding QS in natural infections is vital for developing new antimicrobial strategies against drug-resistant bacteria.

Keywords:
cell–cell signalingpathogenquorum sensingvirulence

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Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Molecular Biology

Background:

  • Bacteria communicate using quorum sensing (QS), a system regulating social behaviors.
  • QS mechanisms are well-understood at the molecular level and often linked to bacterial virulence.
  • QS influences virulence in both human and plant pathogenic bacteria.

Purpose of the Study:

  • To review the role of quorum sensing during infections in various organisms.
  • To highlight approaches for better understanding QS in human infections.
  • To address the gap in knowledge regarding QS function in natural infections.

Main Methods:

  • Literature review of quorum sensing research.
  • Analysis of QS-mediated virulence in different host models (animal and plant).
  • Discussion of experimental approaches to study QS in vivo.

Main Results:

  • QS significantly impacts virulence determinants and overall virulence in laboratory infections.
  • QS mutants are often found in natural infections, suggesting complex roles.
  • The precise function of QS during natural infection and pathogenesis remains incompletely understood.

Conclusions:

  • Quorum sensing plays a complex role in bacterial infections, extending beyond laboratory findings.
  • Further research into QS during natural infections is critical.
  • Understanding QS is essential for developing novel strategies to combat antimicrobial resistance.