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Published on: March 1, 2019
NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2
Cecilia Vial1, Juan Francisco Calderón1, Andrés D Klein1
1Centro de Genetica y Genomica, Facultad de Medicina, Clinica Alemana Universidad del Desarrollo, Santiago, Chile.
Abstract:
The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.
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