Related Experiment Video
Updated: Dec 15, 2025
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
12.4K
Choroidal origin of endogenous Candida endophthalmitis
Mark P Breazzano1,2,3,4
1Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York-Presbyterian Hospital, 635 W 165th St, New York, NY, 10032, USA. mbreazz1@jhmi.edu.
BMC Ophthalmology
|July 15, 2020
Summary
Endogenous Candida endophthalmitis (ECE) primarily involves the choroid. New spectral-domain optical coherence tomography (SD-OCT) classifications may misinterpret retinal findings as primary ECE lesions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Infectious Diseases
Background:
- Endogenous Candida endophthalmitis (ECE) is traditionally understood to originate in the choroid, based on histopathological studies.
- Recent imaging studies using spectral-domain optical coherence tomography (SD-OCT) propose alternative classifications for ECE.
Discussion:
- SD-OCT imaging may be limited by posterior shadowing artifacts, obscuring underlying choroidal pathology.
- Retinal findings like infarction can be mistaken for primary ECE lesions on SD-OCT.
- Accurate characterization of ECE requires careful consideration of these imaging limitations.
Key Insights:
- ECE's primary origin may be misinterpreted with SD-OCT due to artifacts and limited visualization of the choroid.
- Established histopathological findings emphasize choroidal involvement, contrasting with some SD-OCT interpretations.
- A critical review of SD-OCT findings in ECE is necessary to reconcile imaging data with pathology.
Outlook:
- Further research should focus on validating SD-OCT findings with multimodal imaging and histopathology.
- Refined SD-OCT interpretation guidelines are needed to accurately diagnose ECE and its primary site.
- Understanding the true anatomical origin of ECE is crucial for effective treatment strategies.
