Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is propofol a safe agent in porphyria?

P M Weir1, B P Hodkinson

  • 1Department of Anaesthesia, Auckland Hospital, New Zealand.

Anaesthesia
|December 1, 1988
PubMed
Summary

Propofol infusion for anesthesia in a patient with variegate porphyria caused a significant increase in urinary porphyrins. However, no clinical symptoms of a porphyric attack were observed during or after anesthesia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing stress responses in the pre-bypass phase of open heart surgery in infants and young children: a comparison of different fentanyl doses.

British journal of anaesthesia·2000
Same author

Regional anaesthesia for circumcision. Subcutaneous ring block of the penis and subpubic penile block compared.

European journal of anaesthesiology·1997
Same author

Critical incident 10 years later--ability to cope and other behavioural factors.

Anaesthesia·1993
Same author

Propofol infusion and the incidence of emesis in pediatric outpatient strabismus surgery.

Anesthesia and analgesia·1993
Same author

Are you getting the message? A look at the communication between the Department of Health, manufacturers and anaesthetists.

Anaesthesia·1991
Same author

Axillary vein cannulation in neonates.

Critical care medicine·1991

Area of Science:

  • Anesthesiology
  • Biochemistry
  • Medical Genetics

Background:

  • Variegate porphyria (VP) is a rare inherited metabolic disorder affecting heme synthesis.
  • Anesthetic agents can potentially trigger acute porphyric attacks in susceptible individuals.
  • Propofol is a commonly used intravenous anesthetic agent.

Observation:

  • A case study involving a patient with diagnosed variegate porphyria undergoing anesthesia.
  • The anesthetic regimen included a propofol infusion.

Findings:

  • Urinary screening revealed a marked increase in porphyrin levels post-propofol administration.
  • Despite elevated porphyrins, the patient exhibited no clinical signs or symptoms of an acute porphyric crisis.

Implications:

  • This case suggests that propofol may induce subclinical biochemical changes in VP patients.
  • Further research is needed to fully understand propofol's safety profile in variegate porphyria.
  • Monitoring porphyrin levels could be a valuable adjunct in managing VP patients under anesthesia.

Related Experiment Videos