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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Opioid Research: Past and Future.

Rita J Valentino1, Nora D Volkow2

  • 1National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland valentinorj@nida.nih.gov.

Molecular Pharmacology
|July 15, 2020
PubMed
Summary

The International Narcotics Research Conference (INRC) has shaped opioid research for 50 years. Advances in technology now accelerate efforts to prevent and treat opioid use disorder.

Area of Science:

  • Opioid research
  • Pharmacology
  • Neuroscience

Background:

  • The International Narcotics Research Conference (INRC) has convened experts in opioid research for 50 years.
  • It serves as a key forum for knowledge exchange, discussion of controversies, and dissemination of discoveries in opioid science.

Purpose of the Study:

  • To highlight the INRC's historical impact on opioid research.
  • To emphasize the role of emerging technologies in advancing the prevention and treatment of opioid use disorder.

Main Methods:

  • This perspective reviews the evolution of opioid research influenced by the INRC.
  • It discusses current technological advancements and their application to opioid use disorder.

Main Results:

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  • The INRC has been instrumental in guiding the direction of opioid research.
  • New tools and models are enhancing our capacity to address opioid use disorder.

Conclusions:

  • The INRC's legacy is significant in advancing opioid science.
  • Technological progress is crucial for future breakthroughs in preventing and treating opioid use disorder.