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Published on: December 23, 2020
Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses
Maria Smith1,2, Rebekah Honce2,3, Stacey Schultz-Cherry4
1St. Jude Graduate School of Biomedical Sciences, Memphis, Tennessee, USA.
Abstract:
Metabolic syndrome increases the risk of severe disease due to viral infection. Yet few studies have assessed the pathogenesis of respiratory viruses in high-risk populations. Here, we summarize how metabolic dysregulation impairs immune responses, and we define the role of metabolism during influenza virus and coronavirus infections. We also discuss the use of various in vitro, in vivo, and ex vivo models to elucidate the contributions of host factors to viral susceptibility, immunity, and disease severity.
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