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mRNA structural dynamics shape Argonaute-target interactions

Suzan Ruijtenberg1,2, Stijn Sonneveld1, Tao Ju Cui3

  • 1Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands.

Nature Structural & Molecular Biology
|July 15, 2020
PubMed
Summary

Small interfering RNAs (siRNAs) degrade RNA, but target site accessibility is key. Ribosomes unmask target sites, overcoming RNA-RNA interactions that block Argonaute2 (AGO2) binding and cleavage.

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