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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
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Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
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Related Experiment Video

Updated: Dec 15, 2025

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
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Circadian Rhythms in Environmental Health Sciences.

Jacqueline M Leung1, Micaela E Martinez2

  • 1Department of Environmental Health Sciences, Columbia University, 630 West 168th Street, Room 16-421C, New York, NY, USA.

Current Environmental Health Reports
|July 15, 2020
PubMed
Summary

Circadian rhythms, the body's internal clocks, significantly impact disease susceptibility and how environmental exposures affect health. Understanding these biological rhythms is crucial for environmental health research and disease prevention strategies.

Keywords:
AsthmaBiomarkersBreast cancerCircadian rhythmsDNA methylationEnvironmental health

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Area of Science:

  • Chronobiology
  • Environmental Health
  • Molecular and Cellular Biology

Background:

  • Circadian rhythms are fundamental to human physiology, operating at molecular, cellular, and physiological levels.
  • These rhythms influence critical processes such as oxidative stress response, cell trafficking, and hormone production.
  • While prevalent in mammals, circadian rhythms are understudied in environmental health.

Purpose of the Study:

  • To explore the influence of circadian rhythms on disease susceptibility.
  • To investigate how environmental exposures interact with circadian rhythms.
  • To identify biomarkers relevant to both environmental health and chronobiology.

Main Methods:

  • Literature review of chronobiology and environmental health studies.
  • Identification of overlapping biomarkers.
  • Analysis of existing research on circadian rhythms and physiological processes.

Main Results:

  • Circadian clocks regulate physiological and behavioral processes impacting exposure pathways and disease.
  • Circadian rhythms are essential for human physiology and influence disease response.
  • Time-of-day may be a critical factor in environmental health studies.

Conclusions:

  • Circadian rhythms play a significant role in environmental health and disease etiology.
  • Further research is needed on the interplay between environmental exposures and circadian rhythms.
  • Considering time-of-day in environmental health studies is essential.