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Microvascular effects of microneedle application.

Johannes Hackethal^1,2, Fredrik Iredahl^3,4, Joakim Henricson^5,6

¹Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)

|July 15, 2020

Summary

Microneedle skin pretreatment enhances transdermal drug delivery by increasing red blood cell concentration for up to 24 hours. Optimizing microneedle parameters is crucial for effective drug delivery and experimental studies.

Keywords:

TiVi imaging microneedles skin provocation

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Area of Science:

Biomedical Engineering
Dermatology
Pharmacology

Background:

Transdermal drug delivery efficiency can be improved using microneedle pretreatment.
The specific impact of microneedles on skin microvasculature, especially with vasoactive drugs, requires further investigation.

Purpose of the Study:

To investigate the microvascular response to microneedle-induced skin microtraumas.
To assess the effects of varying microneedle sizes, pressures, and application times on skin microcirculation.

Main Methods:

Utilized polarized light spectroscopy imaging (Tissue Viability imaging, TiVi) in eight healthy subjects.
Measured microvascular response for up to 48 hours post-microneedle application.
Tested three microneedle sizes (300 µm, 500 µm, 750 µm) with varied pressures and application durations.

Main Results:

Microneedle application led to a sustained increase in local red blood cell (RBC) concentration.
This increase lasted up to 24 hours, influenced by microneedle length, application time, and applied force.

Conclusions:

Microneedle size, applied pressure, and duration significantly affect the microvascular response.
These parameters require careful optimization for future transdermal drug delivery protocols and experimental designs.