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Nuances to precision dosing strategies of targeted cancer medicines

Ashley M Hopkins1, Bradley D Menz2, Michael D Wiese3

  • 1College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Pharmacology Research & Perspectives
|July 15, 2020
PubMed

Insights

Optimizing targeted cancer drug doses improves patient outcomes. Future studies should integrate exposure, toxicity, and patient preferences for precision dosing strategies.

Area of Science:

  • Pharmacology
  • Oncology
  • Clinical Pharmacy

Background:

  • Individualized dosing of targeted cancer therapies is crucial for maximizing efficacy and minimizing side effects.
  • Current precision dosing strategies often focus on single markers like concentration or toxicity.

Purpose of the Study:

  • To comprehensively review and compare prospective study options for optimizing targeted cancer medicine doses.
  • To highlight the need for integrated approaches in precision dosing.

Main Methods:

  • Review of prospective studies on dose optimization strategies for targeted cancer therapies.
  • Analysis of commonly used markers for dose adaptation (concentration, toxicity, therapeutic outcomes).

Main Results:

  • Precision initial dose selection for targeted therapies is underexplored.
  • On-therapy dose adaptation frequently relies on single markers, but a multifactorial approach is needed.
  • Optimal outcomes require considering exposure, toxicity, therapeutic results, disease status, treatment duration, and patient preferences.

Conclusions:

  • Current precision dosing strategies for targeted cancer medicines are limited.
  • Future prospective studies must incorporate multiple factors for robust precision dosing strategies.
  • Implementing precision dosing requires a holistic approach considering diverse patient-specific elements.
Keywords:
initial dose selectionon-therapy dose adaptationprecision dosingprospective studiestargeted cancer medicines

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