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Updated: Dec 15, 2025

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Innovative therapies for invasive fungal infections in preclinical and clinical development

Yidong Yu1, Krystyna Albrecht2, Jürgen Groll2

  • 1Interdisciplinary Center for Clinical Research Laboratory for Experimental Stem Cell Transplantation, Department of Internal Medicine II, University Hospital of Würzburg , Würzburg, Germany.

Expert Opinion on Investigational Drugs
|July 15, 2020
PubMed
Abstract

Insights

New antifungal drugs and delivery methods are crucial for combating rising invasive fungal infections (IFIs). Current treatments face challenges like resistance and toxicity, highlighting the need for novel antifungal agents.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive fungal infections (IFIs) are a growing global health concern.
  • Existing antifungal therapies (polyenes, azoles, echinocandins, flucytosine) have significant limitations including toxicity, drug interactions, and emerging resistance.
  • There is a critical need for novel antifungal agents to address these challenges.

Purpose of the Study:

  • To review emerging synthetic antifungal drugs with novel mechanisms of action.
  • To explore innovative in vivo drug delivery strategies for antifungals.
  • To highlight the urgent need for expanding the antifungal drug pipeline.

Main Methods:

  • Literature review of preclinical and clinical investigations.
  • Analysis of novel antifungal drug classes.
  • Examination of advanced drug delivery systems.

Main Results:

  • Identification of new synthetic antifungal drug candidates.
  • Exploration of innovative strategies for antifungal drug delivery.
  • Emphasis on the limitations of current antifungal treatments.

Conclusions:

  • Expanding the antifungal drug pipeline is essential to overcome resistance, toxicity, and drug-drug interactions.
  • Novel antifungal agents and improved delivery systems are critical for managing IFIs.
  • The unmet medical need for effective antifungals must be addressed urgently.
Keywords:
APX001GPI biosynthesis inhibitorT-2307antifungal resistancemitochondrial function disrupternovel antifungalsolorofimpyrimidine biosynthesis inhibitorsiderophore analog

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