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Genetic variants associated with rotator cuff tearing utilizing multiple population-based genetic resources

Robert Z Tashjian1, Stuart K Kim2, Megan D Roche3

  • 1Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, USA.

Journal of Shoulder and Elbow Surgery
|July 15, 2020
PubMed
Summary

This study identified novel genetic variants in ZNF804A, GLCCI1, and THSD7A associated with rotator cuff tearing. Gene expression analysis revealed THSD7A downregulation and upregulation of TIMP2, Col5A1, TGFBR1, and TNC in rotator cuff tears.

Keywords:
RNA sequencingRotator cuffgenome-wide association study

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