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3D high spatial resolution visualisation and quantification of interconnectivity in polymer films.

C Fager1, S Barman2, M Röding3

  • 1Department of Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

International Journal of Pharmaceutics
|July 15, 2020
PubMed
Summary

This study introduces a new 3D analysis method to visualize and quantify pore network interconnectivity in drug release films. Higher interconnectivity in ethyl cellulose/hydroxypropyl cellulose films correlates with improved drug transport properties.

Keywords:
3DBottlenecksFocused ion beamGeodesic channelsGeodesic pathsInterconnectivityPolymerPorosityScanning electron microscopyVisualisation

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmacology

Background:

  • Porous networks in drug delivery films are crucial for controlled release, with interconnectivity dictating transport properties.
  • Quantifying this interconnectivity is essential for designing and optimizing drug release films.
  • Existing methods may not fully capture the complex 3D structure of these networks.

Purpose of the Study:

  • To develop and present a novel method for the 3D visualization and quantitative analysis of pore network interconnectivity in drug release films.
  • To correlate the quantified interconnectivity with experimentally observed drug transport properties.
  • To provide a tool for the improved design and control of advanced drug delivery systems.

Main Methods:

  • Acquisition of high-resolution 3D datasets using focused ion beam scanning electron microscopy (FIB-SEM).
  • Development of a data analysis technique for visualizing and segmenting pore paths based on length.
  • Identification of central network features by analyzing coinciding pore paths.

Main Results:

  • The novel method successfully visualized and quantified pore path interconnectivity in ethyl cellulose/hydroxypropyl cellulose films.
  • Increased hydroxypropyl cellulose content led to higher porosity and interconnectivity.
  • Analysis results aligned with experimentally measured drug release rates, confirming the method's validity.
  • A significant bottleneck effect was observed in films with lower porosity.

Conclusions:

  • The developed 3D analysis method provides a powerful tool for understanding and quantifying pore network interconnectivity in porous films.
  • Interconnectivity is a key factor influencing drug release kinetics, and its quantification enables better film design.
  • This approach facilitates the correlation between material structure and functional performance in controlled drug release applications.