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[Diabetes mellitus and the intestinal nervous system]
1II. Medizinische Klinik Technischen Universität, München.
Zeitschrift Fur Gastroenterologie
|April 1, 1988
Summary
Diabetic rats showed impaired enteric nerve function, with a lack of key peptide release during electrical stimulation. This suggests nerve dysfunction contributes to gastrointestinal issues in diabetes.
Area of Science:
- Neurogastroenterology
- Diabetic complications
- Vascular biology
Background:
- Diabetes mellitus is associated with gastrointestinal dysfunction.
- Enteric nerves regulate gut motility and secretion through peptide release.
- Vasoactive intestinal polypeptide (VIP) and calcitonin gene-related peptide (CGRP) are crucial neurotransmitters in the enteric nervous system.
Purpose of the Study:
- To investigate the release of VIP and CGRP from enteric nerves in a rat model of diabetes.
- To determine if streptozotocin-induced diabetes affects the neurovascular function of the enteric nervous system.
Main Methods:
- Electrical field stimulation of enteric nerves in isolated segments of the rat colon.
- Measurement of VIP and CGRP release using radioimmunoassay.
- Comparison between streptozotocin-diabetic rats and control rats.
Main Results:
- Electrical stimulation failed to elicit the release of VIP and CGRP in diabetic rats.
- A significant reduction in basal and stimulated release of both peptides was observed in diabetic rats compared to controls.
- These findings indicate a deficit in the neurosecretory function of enteric nerves in this diabetic model.
Conclusions:
- Streptozotocin-induced diabetes impairs the release of VIP and CGRP from enteric nerves.
- This deficiency in key neuropeptides may underlie the gastrointestinal dysmotility observed in diabetes.
- Restoring VIP and CGRP function could be a therapeutic target for diabetic gastrointestinal complications.