Related Experiment Video

Updated: Dec 15, 2025

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.5K

Identification of Target Genes in Hypertension and Left Ventricular Remodeling

Bo Pang1, Cong Hu2,3, Guodong Wu1

  • 1Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin.

Medicine
|July 16, 2020
PubMed

Insights

This study identifies 21 overexpressed genes linked to hypertension and left ventricular remodeling. These findings offer potential targets for diagnosing and treating hypertensive heart disease.

Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • Bioinformatics

Background:

  • Hypertension is a global health issue with left ventricular (LV) remodeling as a known complication.
  • The precise mechanisms driving hypertension-induced LV remodeling remain largely unknown.

Purpose of the Study:

  • To identify differentially expressed genes in hypertension and LV remodeling.
  • To elucidate the underlying molecular mechanisms and potential therapeutic targets.

Main Methods:

  • Utilized the Gene Expression Omnibus (GEO) database for gene expression profiling.
  • Performed integrated bioinformatics analysis using GeneMANIA, DAVID, and CTD databases.
  • Identified transcription factors (TFs) associated with differentially expressed genes (DEGs).

Main Results:

  • Identified 21 genes overexpressed in both hypertension and hypertensive LV remodeling.
  • DEGs are enriched in cellular amino acid metabolism, antigen processing, and proteasome complex pathways.
  • Key TFs (HAND1, E4BP4, ESR1, VBP, ELK-1, POU3F2) were identified as crucial for LV remodeling in hypertension.

Conclusions:

  • Bioinformatic analysis revealed targeted genes associated with LV remodeling in hypertension.
  • These findings provide potential biomarkers for prognosis and novel targets for pharmacological intervention.
Abstract

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.8K
A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

3.3K

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
773
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
558
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
249
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
584
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.5K