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Ferroptosis in Liver Diseases: An Overview
Martina Maria Capelletti1,2, Hana Manceau1,3, Hervé Puy1,4
1Centre de Recherche sur l'Inflammation, INSERM U1149, Université de Paris, Laboratory of Excellence GR-Ex, 75018 Paris, France.
International Journal of Molecular Sciences
|July 16, 2020
Summary
Ferroptosis, a cell death form, involves iron and lipid peroxides. This review details ferroptosis mechanisms, its role in liver diseases, and its therapeutic potential for liver cancer.
Area of Science:
- Biochemistry
- Cell Biology
- Pathology
Background:
- Ferroptosis is a distinct iron-dependent cell death pathway.
- It is characterized by lipid peroxide accumulation and redox imbalance.
- Key features include GPX4 inactivation and PUFA oxidation.
Purpose of the Study:
- To comprehensively analyze ferroptosis mechanisms.
- To review ferroptosis inducers and inhibitors.
- To discuss ferroptosis's role in liver diseases and cancer therapy.
Main Methods:
- Literature review of ferroptosis mechanisms.
- Analysis of pathways influencing ferroptosis.
- Examination of ferroptosis's involvement in hepatic disorders.
Main Results:
- Ferroptosis is regulated by iron metabolism, GPX4, and phospholipid pathways.
- It is implicated in acute kidney injury, cancer, and liver diseases.
- Therapeutic strategies targeting ferroptosis are emerging.
Conclusions:
- Ferroptosis is a critical cell death mechanism with broad pathological relevance.
- Understanding ferroptosis offers new avenues for treating liver diseases.
- Targeting ferroptosis shows promise for hepatocellular carcinoma treatment.
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