Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin 6: identification as a hematopoietic colony-stimulating factor.

G G Wong1, J Witek-Giannotti, R M Hewick

  • 1Genetics Institute, Inc., Cambridge, MA 02140.

Behring Institute Mitteilungen
|August 1, 1988
PubMed
Summary

Interleukin 6 (IL-6) is a key cytokine with diverse roles in immune responses. This study identifies IL-6

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delay of adequate empiric antibiotic therapy is associated with increased mortality among solid-organ transplant patients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2009
Same author

Over-expression of FoxM1 stimulates cyclin B1 expression.

FEBS letters·2001
Same author

Isolated inferior rectus muscle palsy resulting from a nuclear third nerve lesion as the initial manifestation of multiple sclerosis.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2000
Same author

Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription.

Molecular and cellular biology·1999
Same author

Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.

The Journal of biological chemistry·1997
Same author

Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas.

Proceedings of the National Academy of Sciences of the United States of America·1994

Area of Science:

  • Immunology
  • Hematology
  • Cell Biology

Background:

  • Interleukin 6 (IL-6) is a pleiotropic cytokine influencing various cell types, including B cells, T cells, and hepatocytes.
  • Its role in hematopoietic processes was not fully elucidated prior to this study.

Purpose of the Study:

  • To identify and characterize a novel myeloid colony-stimulating activity.
  • To demonstrate the effects of IL-6 on hematopoietic target cells.

Main Methods:

  • Molecular cloning of a cDNA encoding a novel myeloid colony-stimulating activity from a human T cell line.
  • Assays to evaluate the colony-forming activity of IL-6 on hematopoietic cells, including synergistic effects with IL-3.

Main Results:

  • A novel myeloid colony-stimulating activity was identified and found to be identical to Interleukin 6 (IL-6).
  • IL-6 demonstrated effects on hematopoietic target cells, supporting granulocyte-macrophage colony formation.
  • IL-6 acted synergistically with IL-3 to support primitive blast cell colony formation in both murine and human systems.

Conclusions:

  • IL-6 possesses significant hematopoietic-stimulating activities, impacting myeloid progenitor cells.
  • IL-6 plays a crucial role in the cytokine network, integrating host responses, particularly in infection.
  • The findings highlight IL-6's importance in hematopoiesis and immune regulation.

Related Experiment Videos