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The molecular cloning of interleukins 4, 5 and 6: multifunctional hemopoietic growth factors
We summarize here our recent studies on the cloning and characterization of three lymphokines which are produced by activated T cells. Interleukins 4, 5 and 6 are involved in the regulation of B cell activation, proliferation and differentiation. IL-4 can activate resting B cells, while IL-5 stimulates the proliferation of activated B cells. Both of these factors also have a role in regulating the isotype of immunoglobulin produced by cultures of D cells. IL-6 appears to induce the differentiation of B cells to secrete high levels of immunoglobulin. In addition, each of these factors is involved in the regulation of other lineages of hemopoietic cells. Thus, T cells control multiple lineages of myeloid and lymphoid cells through the diverse actions of multiple lymphokines. IL-6 is exceptional because it is produced by a variety of cell types, and its action is not restricted to hemopoietic cells.
We summarize here our recent studies on the cloning and characterization of three lymphokines which are produced by activated T cells. Interleukins 4, 5 and 6 are involved in the regulation of B cell activation, proliferation and differentiation. IL-4 can activate resting B cells, while IL-5 stimulates the proliferation of activated B cells. Both of these factors also have a role in regulating the isotype of immunoglobulin produced by cultures of D cells. IL-6 appears to induce the differentiation of B cells to secrete high levels of immunoglobulin. In addition, each of these factors is involved in the regulation of other lineages of hemopoietic cells. Thus, T cells control multiple lineages of myeloid and lymphoid cells through the diverse actions of multiple lymphokines. IL-6 is exceptional because it is produced by a variety of cell types, and its action is not restricted to hemopoietic cells.