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Acetic acids bearing the 1-phenyl-1H-indazole nucleus with analgesic and antiinflammatory activity
L Mosti1, G Menozzi, P Schenone
1Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
Il Farmaco; Edizione Scientifica
|October 1, 1988
Abstract:
The synthesis of [(1-phenyl-1H-indazol-4-yl)oxy]acetic acid (IV), (1-phenyl-1H-indazol-4-yl)acetic acid (IX) and (1,5,6,7)tetrahydro-1-phenyl-4H-indazol-4-iminooxy)acetic acid (XIII) starting from 1,5,6,7-tetrahydro-1-phenyl-4H-indazol-4-one (I) is described. These compounds showed a good antiinflammatory activity in rats, and an analgesic activity in mice similar or comparable to that of indomethacin.