Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

333
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
333

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining Non-Contrast CT Radiomics with MR PREDICTS Improves Prediction of Futile Recanalization after Mechanical Thrombectomy.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same author

The Association of Headache and Physical Activity in Times of the COVID-19 Pandemic: A Prospective Cohort Study.

Brain and behavior·2026
Same author

Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine.

The journal of headache and pain·2026
Same author

Erenumab and OnabotulinumtoxinA in Chronic Migraine: A Comparative Analysis.

European journal of neurology·2026
Same author

Is achieving higher standards in real-world migraine care feasible with anti-CGRP monoclonal antibodies preventive therapies?: Insights from the EUREkA cohort.

Cephalalgia : an international journal of headache·2026
Same author

Efficacy, IHS Guideline Adherence, and Methodological Quality of Noninvasive Neuromodulation Clinical Trials in Migraine and Cluster Headache: A Systematic Review.

European journal of neurology·2026

Related Experiment Video

Updated: Dec 14, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K

Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence.

Silvia Benemei1, Alejandro Labastida-Ramírez2, Ekaterina Abramova3

  • 1Health Sciences Department, University of Florence and Headache Centre, Careggi University Hospital, Florence, Italy.

The Journal of Headache and Pain
|July 16, 2020
PubMed
Summary

Post-traumatic headache (PTH) following traumatic brain injury (TBI) is common but not fully understood. Animal models are crucial for investigating PTH mechanisms and developing treatments, despite their limitations.

Keywords:
Animal modelsHeadacheMigrainePainTraumatic brain injury

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.2K

Related Experiment Videos

Last Updated: Dec 14, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.2K

Area of Science:

  • Neurology
  • Neuroscience
  • Traumatology

Background:

  • Post-traumatic headache (PTH) is a secondary headache disorder following traumatic brain injury (TBI).
  • PTH is defined by its onset within 7 days of head injury or regaining consciousness.
  • Persistent PTH lasts longer than 3 months.

Purpose of the Study:

  • To review the current understanding of post-traumatic headache (PTH) mechanisms.
  • To highlight the role and limitations of animal models in studying PTH.
  • To emphasize the need for further research into PTH pathophysiology.

Main Methods:

  • Preclinical studies using various animal models of mild TBI were reviewed.
  • Animal models were evaluated for their ability to reproduce conditions leading to PTH.
  • Models were assessed for proximity to human conditions and experimental reproducibility.

Main Results:

  • Animal models provide valuable in vivo insights into PTH pathophysiology.
  • Different models replicate various trauma types, aiding mechanistic studies.
  • Despite limitations, animal models are essential for understanding PTH.

Conclusions:

  • PTH mechanisms, particularly those overlapping with migraine, require further clarification.
  • Understanding available animal models is vital for researchers investigating PTH.
  • Continued research using animal models is necessary to unravel PTH mechanisms.