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Rad50 mediates DNA demethylation to establish pluripotent reprogramming

Hanseul Park1,2, Byounggook Cho1,2, Jongpil Kim3,4

  • 1Laboratory of Stem Cells & Gene Editing, Department of Biomedical Engineering, Dongguk University, Seoul, 100-715, Republic of Korea.

Experimental & Molecular Medicine
|July 16, 2020
PubMed
Summary

Rad50 protein is crucial for DNA demethylation, a process vital for generating induced pluripotent stem cells (iPSCs). Its presence enhances reprogramming efficiency, while its absence hinders it.

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