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Multimodality Diagnosis of Mesenteric Ischemia

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Published on: July 21, 2023

Kikuchi-Fujimoto Syndrome: A Rare Entity to Consider.

Diogo Raposo André¹, Filipa Vicente¹, Jessica Chaves¹

¹Internal Medicine Department, Hospital Central do Funchal, Madeira Island, Portugal.

European Journal of Case Reports in Internal Medicine

|July 16, 2020

Summary

Kikuchi-Fujimoto disease (KFD) is a rare lymphadenitis presenting with fever and swollen lymph nodes. Early diagnosis is key to avoid misdiagnosis and aggressive treatments, as KFD can mimic other serious conditions.

Keywords:

Kikuchi-Fujimoto disease fever of unknown origin lymphadenitis rare disease

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Published on: October 14, 2021

Area of Science:

Pathology
Immunology
Infectious Diseases

Background:

Kikuchi-Fujimoto disease (KFD) is a rare, benign necrotizing lymphadenitis of unknown cause.
It typically presents with cervical lymphadenopathy, fever, and nocturnal diaphoresis.
Diagnosis relies on histopathological study and immunophenotyping of lymph node biopsies.

Purpose of the Study:

To highlight the diverse clinical presentations of KFD.
To emphasize the importance of considering KFD in the differential diagnosis of fever of unknown origin.
To discuss the potential for KFD to evolve into autoimmune disorders.

Main Methods:

Case series describing five patients with KFD.
Inclusion of patients with atypical presentations and varied etiologies.
Review of diagnostic challenges and treatment implications.

Main Results:

KFD can present atypically, mimicking conditions like pyelonephritis.
Misdiagnosis leading to unnecessary chemotherapy occurred in some cases.
Cytomegalovirus was identified as a potential etiological agent in one case.
One patient developed an autoimmune condition following KFD.

Conclusions:

KFD is a rare condition that can mimic infectious, autoimmune, and neoplastic diseases.
It requires inclusion in the differential diagnosis for unexplained cervical lymphadenopathy and fever.
While often self-limiting, KFD carries a risk of subsequent autoimmune syndrome development.