Related Experiment Video

Updated: Dec 14, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.2K

Characteristics of the Coronavirus Disease 2019 and related Therapeutic Options

Boxuan Huang1, Rongsong Ling1, Yifan Cheng1

  • 1Institute for Advanced Study, Shenzhen University, Shenzhen 518052, Guangdong, China.

Molecular Therapy. Methods & Clinical Development
|July 16, 2020
PubMed

Insights

The novel coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, requires urgent therapeutic drug development due to its high infectivity and mortality. This review explores COVID-19

Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Coronavirus disease 2019 (COVID-19) is a severe global health crisis caused by SARS-CoV-2.
  • The virus is highly infectious, has a prolonged incubation period, and a significant mortality rate.
  • Existing treatments are limited, necessitating the urgent development of effective therapeutic drugs.

Purpose of the Study:

  • To review the structure, genome, and replication mechanisms of SARS-CoV-2.
  • To summarize the clinical manifestations, diagnosis, and current treatment strategies for COVID-19.
  • To discuss potential molecular targets and drug development approaches for COVID-19 treatment.

Main Methods:

  • Literature review of SARS-CoV-2 structure, infection, and replication.
  • Compilation of clinical data on COVID-19 symptoms, diagnosis, and treatments.
  • Analysis of ongoing drug development strategies and clinical trials for COVID-19 therapeutics and vaccines.

Main Results:

  • Detailed overview of SARS-CoV-2 characteristics and its infection pathway.
  • Summary of clinical features and diagnostic criteria for COVID-19.
  • Exploration of various therapeutic targets and drug development pipelines, including vaccine progress.

Conclusions:

  • The urgent need for effective COVID-19 treatments is highlighted.
  • Potential therapeutic targets and drug development strategies are identified.
  • Insights into clinical trials and vaccine development offer a path forward for managing the pandemic.

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.7K
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

5.1K

Related Concept Videos

Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
167
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
3.0K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
780
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
646