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Parental occupational exposure pre- and post-conception and development of asthma in offspring

Kathrine Pape1,2, Cecile Svanes3,4, Camilla S Sejbæk1

  • 1National Research Center for the Working Environment, Copenhagen, Denmark.

International Journal of Epidemiology
|July 16, 2020
PubMed

Insights

Parental occupational exposures before conception did not link to childhood asthma. However, maternal exposure to allergens and chemicals pre- and post-conception showed a slight increase in early-onset asthma in offspring.

Area of Science:

  • Environmental Health
  • Epidemiology
  • Pediatric Respiratory Health

Background:

  • Growing evidence suggests occupational exposures impact respiratory health.
  • Emerging research explores the effects of parental pre-conception occupational exposures on offspring respiratory health.

Purpose of the Study:

  • To investigate the association between parental occupational exposures before conception and asthma development in offspring aged 0-15 years.

Main Methods:

  • Utilized data from 3985 offspring in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) study.
  • Linked parental job history (pre- and post-conception) to an asthma-specific job-exposure matrix (JEM).
  • Employed logistic regression models, adjusting for various familial and individual factors.

Main Results:

  • No significant association found between parental occupational exposure (microorganisms, pesticides, allergens, reactive chemicals) before conception and offspring asthma.
  • Maternal exposure to allergens and reactive chemicals both pre- and post-conception was linked to increased odds of early-onset asthma (0-3 years).

Conclusions:

  • The study found no general evidence linking parental occupational exposure before conception to offspring asthma.
  • A potential association was observed for maternal exposure to specific agents during both pre- and post-conception periods with early-onset childhood asthma.
Abstract

Keywords:
job-exposure matricesEpidemiologyair pollutantsasthmageneration studyoccupationoccupational exposure

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