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State-of-the-Art Traditional to the Machine- and Deep-Learning-Based Skull Stripping Techniques, Models, and
Anam Fatima1, Ahmad Raza Shahid1, Basit Raza2
1Medical Imaging and Diagnostics (MID) Lab, National Centre of Artificial Intelligence (NCAI), Department of Computer Science, COMSATS University Islamabad (CUI), Islamabad, 45550, Pakistan.
Journal of Digital Imaging
|July 16, 2020
Summary
Skull stripping, essential for brain MRI analysis, is transitioning to automated methods. Deep learning shows superior performance over traditional techniques for accurate brain segmentation, despite some limitations.
Area of Science:
- Neuroimaging
- Medical Image Analysis
- Artificial Intelligence
Background:
- Skull stripping is a critical preprocessing step in neuroimaging, particularly for brain magnetic resonance imaging (MRI).
- Accurate skull stripping is vital for clinical analysis and diagnostic purposes in brain segmentation tasks.
- Challenges arise from complex brain anatomy and intensity variations in MRI, making precise differentiation between brain and skull difficult.
Purpose of the Study:
- To analyze the evolution of skull stripping methods from conventional to automated machine learning and deep learning approaches.
- To provide a comparative analysis of current state-of-the-art skull stripping techniques.
- To discuss challenges, parameter quantification models, and future research directions in automated skull stripping.
Main Methods:
- Review and comparison of conventional, machine learning, and deep learning-based automated skull stripping methods for brain MRI.
- Analysis of the performance and limitations of different skull stripping techniques.
- Critical discussion of challenges and quantification models.
Main Results:
- Deep learning methods demonstrate superior performance compared to conventional and machine learning techniques in automated skull stripping.
- Despite advancements, deep learning approaches have inherent limitations that require further investigation.
- Comparative analysis highlights the strengths and weaknesses of current state-of-the-art skull stripping methods.
Conclusions:
- Automated skull stripping, especially using deep learning, is advancing neuroimaging analysis.
- Further research is needed to address the limitations of deep learning methods and refine parameter quantification.
- The study provides insights into the current landscape and future trajectory of skull stripping techniques for brain MRI.

