Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

144
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
144
Patient-centered Care01:13

Patient-centered Care

2.8K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
2.8K
Restorative Care01:19

Restorative Care

2.2K
Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
2.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

713
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
713
Anatomical Positions01:11

Anatomical Positions

17.9K
In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
17.9K
Nursing Clinical Information System01:27

Nursing Clinical Information System

1.1K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formulated curcumin exerts potent anti-influenza activity by inhibition of Akt activation and viral genome replication.

Intervirology·2026
Same author

PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis.

Redox biology·2026
Same author

ANTHRACYCLINE-INDUCED CARDIOTOXICITY: MECHANISM AND PREVENTION.

Transactions of the American Clinical and Climatological Association·2025
Same author

Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b.

Cardio-oncology (London, England)·2025
Same author

CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury.

Cellular and molecular life sciences : CMLS·2025
Same author

Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment.

Journal of neurochemistry·2025
Same journal

Long-term potentiation in the brain: A synaptic memory mechanism.

Physiological reviews·2026
Same journal

Catecholamine metabolism revisited: From neurochemistry to integrative physiology and pathophysiology.

Physiological reviews·2026
Same journal

THE ORIGINS AND PROGRESSION OF PYLORIC METAPLASIA FOLLOWING GASTRIC MUCOSAL INJURY.

Physiological reviews·2026
Same journal

AKAP signaling: physiological and pathophysiological roles and opportunities for novel therapeutic concepts.

Physiological reviews·2026
Same journal

Mechanisms of transcranial magnetic brain stimulation.

Physiological reviews·2026
Same journal

Esophageal peristalsis in health and disease: mechanistic insights.

Physiological reviews·2026
See all related articles

Related Experiment Video

Updated: Dec 14, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

768

SUMO: From Bench to Bedside.

Hui-Ming Chang1, Edward T H Yeh1

  • 1Center for Precision Medicine, Department of Medicine, University of Missouri, Columbia, Missouri.

Physiological Reviews
|July 16, 2020
PubMed
Summary
This summary is machine-generated.

The Sentrin/small ubiquitin-like modifier (SUMO) pathway regulates vital biological processes and is implicated in diseases like cancer and diabetes. SUMOylation enzymes offer potential therapeutic targets for human diseases.

Keywords:
SUMOSentrinbiochemistrycancerheartphysiology

More Related Videos

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

7.5K
Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

82.6K

Related Experiment Videos

Last Updated: Dec 14, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

768
SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

7.5K
Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

82.6K

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cell Biology

Background:

  • The Sentrin/small ubiquitin-like modifier (SUMO) pathway is a crucial post-translational modification regulating diverse cellular functions.
  • SUMOylation and de-SUMOylation involve specific enzymatic machinery (E1, E2, E3 enzymes and SENPs).
  • SUMO modification impacts protein localization, activity, stability, and protein-protein interactions.

Purpose of the Study:

  • To review recent advances in understanding SUMO pathway mechanisms in disease pathogenesis.
  • To highlight the roles of SUMOylation in cancer, diabetes, seizure, and heart failure.
  • To discuss the therapeutic potential of targeting SUMO enzymes.

Main Methods:

  • Literature review focusing on SUMOylation and disease mechanisms.
  • Analysis of the enzymatic cascade of SUMO conjugation and deconjugation.
  • Examination of SUMO-1 and SUMO-2/3 modifications and their functional consequences.

Main Results:

  • SUMOylation is essential for cell division, DNA repair, signal transduction, and metabolism.
  • Dysregulation of the SUMO pathway is linked to pathogenesis in cancer, diabetes, seizure, and heart failure.
  • SUMO modification influences protein interactions via SUMO-interactive motifs (SIMs).

Conclusions:

  • The SUMO pathway plays critical roles in nearly all biological processes.
  • SUMOylation and de-SUMOylation biochemistry is relatively straightforward but highly regulated.
  • SUMO enzymes represent promising targets for developing novel therapeutic strategies for human diseases.