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Related Experiment Video

Updated: Dec 14, 2025

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
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Objective assessment of skin microcirculation using a smartphone camera.

Erik Tesselaar1, Simon Farnebo2

  • 1Department of Radiation Physics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|July 16, 2020
PubMed
Summary

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A smartphone app accurately measures skin microcirculation changes. This easy-to-use technology shows reproducible results for assessing vascular responses, offering a portable alternative to costly equipment.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Physiology

Background:

  • Current microcirculation assessment tools are large, expensive, and difficult to use.
  • Smartphone advancements offer new possibilities for portable medical devices.
  • SkinSight utilizes smartphone sensors to measure skin microcirculation changes.

Purpose of the Study:

  • To evaluate the efficacy of the SkinSight smartphone application for assessing skin microcirculation.
  • To measure changes in skin microcirculation during physiological challenges using a mobile device.
  • To compare smartphone-based measurements with established techniques.

Main Methods:

  • A relative hemoglobin (Hb) index was calculated from smartphone camera images.
  • Measurements were taken during arterial occlusion, reactive hyperemia, and venous occlusion in 10 healthy subjects.
Keywords:
hemoglobinmicrocirculationpost-occlusive reactive hyperemiasmartphonevenous occlusion

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  • Skin microcirculation was simultaneously assessed using polarized light spectroscopy imaging.

    • Main Results:

    • The smartphone app demonstrated excellent day-to-day reproducibility (ICC: 0.92).
    • Significant increases in Hb index were observed during venous occlusion and post-arterial occlusion hyperemia (P < .001).
    • Potential variations in measurements were noted due to lighting conditions and calibration.

    Conclusions:

    • Smartphone applications can accurately and reproducibly assess microvascular responses in the skin.
    • SkinSight provides a flexible, handheld method for skin microvascular assessment.
    • Further investigation into lighting effects and calibration is recommended for this mobile technology.