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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Total Synthesis of Macrocyclic Dysoxylactam A

D Prabhakar Reddy1,2, Biao Yu2,3

  • 1Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, 201203, China.

Chemistry, an Asian Journal
|July 16, 2020
PubMed
Summary

The total synthesis of dysoxylactam A, a novel macrolactam, was successfully achieved. This compound exhibits potent multi-drug-resistant reversing activities, offering new therapeutic possibilities.

Keywords:
Aldol reactionDysoxylactam Amacrocyclolipopeptidemulti-drug-resistant agentring-closing metathesis

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