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Updated: Dec 14, 2025

Knee Arthrocentesis in Adults
Published on: February 25, 2022
Juvenile idiopathic arthritis is associated with higher healthcare utilization after total knee or hip replacement
J A Singh1,2,3, J D Cleveland2
1Medicine Service, VA Medical Center , Birmingham, AL, USA.
Insights
Juvenile idiopathic arthritis (JIA) patients undergoing hip or knee replacement surgery experienced higher healthcare costs and longer hospital stays. Patients with JIA also had increased odds of requiring transfusions after knee replacement surgery.
Area of Science:
- Orthopedic Surgery
- Rheumatology
- Health Services Research
Background:
- Juvenile idiopathic arthritis (JIA) is a chronic inflammatory condition affecting children.
- The long-term impact of JIA on adult outcomes after major orthopedic procedures like total hip or knee arthroplasty (THA/TKA) is not well understood.
Purpose of the Study:
- To investigate the association between JIA and healthcare utilization and in-hospital complications following THA/TKA.
- To identify potential disparities in resource use and adverse events in JIA patients undergoing arthroplasty.
Main Methods:
- Utilized the US National Inpatient Sample (1998-2014) for a large-scale retrospective analysis.
- Employed multivariable-adjusted logistic regression to compare outcomes between patients with and without JIA, controlling for demographic and clinical factors.
Main Results:
- Patients with JIA undergoing THA/TKA showed significantly higher odds of exceeding median hospital charges and length of stay.
- JIA patients had increased odds of discharge to non-home settings after THA.
- A higher odds ratio for blood transfusion was observed in JIA patients post-TKA.
Conclusions:
- Juvenile idiopathic arthritis is linked to increased healthcare resource utilization after total hip and knee arthroplasty.
- Patients with JIA demonstrate a higher likelihood of requiring transfusions post-TKA.
- Targeted interventions may be necessary to mitigate elevated resource utilization in JIA patients undergoing arthroplasty.
Abstract:
Objective: To assess whether juvenile idiopathic arthritis (JIA) is associated with healthcare utilization and in-hospital complications after total hip or knee arthroplasty (THA/TKA). Method: We used the 1998-2014 US National Inpatient Sample. We performed multivariable-adjusted logistic regression, adjusted for age, race/ethnicity, gender, income, Deyo-Charlson comorbidity index, insurance payer, and the underlying diagnosis. Results: Of the 4 116 485 THAs and 8 127 282 TKAs, 1882 people with JIA had THAs (0.02%) and 1388 had TKAs (0.01%). Compared to people without JIA, people with JIA post-THA and post-TKA had higher odds ratio [OR (95% confidence interval), respectively] of total hospital charges above the median [1.30 (1.05, 1.60) and 1.37 (1.08, 1.74)], length of hospital stay > 3 days [1.64 (1.27, 2.12) and 1.44 (1.07, 1.93)], and discharge to non-home settings [1.37 (1.07, 1.76)] post-THA, but not post-TKA [1.02 (0.77, 1.36)]. People with JIA also had higher OR of transfusion post-TKA [1.92 (1.44, 2.55)], but not post-THA [1.00 (0.77, 1.30)]. Sensitivity analyses that adjusted for hospital characteristics confirmed the main study findings with minimal or no attenuation of OR. Conclusions: People with JIA utilized more healthcare services post-THA/TKA and were more likely to receive transfusions post-TKA. Interventions to reduce the risk of higher resource utilization are needed in people with JIA.
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