Association Between Ghrelin Gene Polymorphism and Cerebral Infarction.

Area of Science:

• Genetics
• Neurology
• Biochemistry

Background:

• Cerebral infarction (stroke) is a major health concern.
• The role of ghrelin gene polymorphisms in cerebral infarction is not fully understood.

Purpose of the Study:

• To investigate the association between ghrelin gene polymorphisms (rs26312, rs26802, rs27647) and cerebral infarction.
• To explore the relationship between these polymorphisms and clinical parameters.

Main Methods:

• Case-control study with 200 cerebral infarction patients and 200 healthy controls.
• Genotyping of ghrelin gene polymorphisms using DNA sequencing.
• Analysis of associations with clinical markers like APTT, D-dimer, and PT.

Main Results:

• Significant differences in genotype distribution for rs26802 and rs27647 between groups.
• Ghrelin gene expression was lower in cerebral infarction patients with the AA genotype at rs26312.
• Specific genotypes correlated with altered activated partial thromboplastin time (APTT), D-dimer, and prothrombin time (PT).

Conclusions:

• Ghrelin gene polymorphisms are significantly associated with the occurrence of cerebral infarction.
• These findings suggest ghrelin gene variations may influence stroke risk and related coagulation parameters.