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Related Concept Videos

Rh Blood Group01:19

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
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Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Related Experiment Video

Updated: Dec 14, 2025

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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An update on the RAPH blood group system.

Margaret A Keller1

  • 1Senior Director, National Molecular Laboratory, American Red Cross.

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|July 16, 2020
PubMed
Summary
This summary is machine-generated.

The RAPH blood group system, also known as International Society of Blood Transfusion system 25, has no new alleles. This system involves the MER2 antigen on CD151, impacting red blood cells and other tissues.

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Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • The RAPH blood group system, ISBT system 25, is defined by the MER2 antigen.
  • MER2 is expressed on CD151, a tetraspanin protein.
  • CD151 plays a role in cell adhesion and is found on various tissues.

Purpose of the Study:

  • To provide an update on the RAPH blood group system.
  • To report any newly identified alleles within the RAPH system.

Main Methods:

  • Review of existing literature and blood group system data.
  • Analysis of the RAPH blood group system's genetic and antigenic properties.

Main Results:

  • No new alleles have been identified for the RAPH blood group system.
  • The RAPH system comprises a single antigen, MER2, on CD151.
  • CD151 interacts with specific laminin-binding integrins.

Conclusions:

  • The RAPH blood group system remains unchanged with no new alleles reported.
  • Deficiency of the RAPH protein is linked to nephropathy, epidermolysis bullosa, and deafness.
  • CD151's expression on red blood cells and other tissues highlights its broad significance.