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Anti-inflammatory and peripheral analgesic activity of esculetin in vivo
A Tubaro1, P Del Negro, E Ragazzi
1Institute of Pharmacology and Pharmacognosy, University of Trieste, Italy.
Pharmacological Research Communications
|December 1, 1988
Abstract:
Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.
