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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Statins for asthma.

Cho Naing1,2, Han Ni3

  • 1International Medical University, Kuala Lumpur, Malaysia.

The Cochrane Database of Systematic Reviews
|July 16, 2020
PubMed
Summary
This summary is machine-generated.

Limited research on statins for asthma shows insufficient evidence of benefits or harms. More high-quality trials are needed to determine if statins are effective and safe adjunct treatments for asthma.

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Area of Science:

  • Respiratory Medicine
  • Pharmacology

Background:

  • Asthma is a chronic respiratory condition characterized by airway inflammation.
  • Statins, primarily used for lipid-lowering, are being investigated as potential adjunct therapies for asthma.

Purpose of the Study:

  • To evaluate the benefits and harms of statins as an add-on treatment for asthma in adults and children.

Main Methods:

  • A systematic review of randomized controlled trials (RCTs) of at least 12 weeks' duration was conducted.
  • Searches included major databases (Cochrane Airways, CENTRAL, MEDLINE, Embase) and clinical trial registries up to February 7, 2020.

Main Results:

  • Only one small trial with 60 participants comparing atorvastatin to placebo was identified.
  • The trial did not report primary outcomes or adverse events, leading to uncertainty regarding the effects on lung function (FEV1, PEF).
  • The included study had data discrepancies and did not report serious adverse effects.

Conclusions:

  • The current evidence is of very low certainty, precluding conclusions on the effectiveness and safety of statins for asthma.
  • High-quality, large-scale, multicenter RCTs with longer durations are necessary to assess statin efficacy, safety, and impact on asthma management.
  • Future research should also investigate subgroups, such as individuals with obesity and asthma.