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Single centre 30-year experience in treating retroperitoneal liposarcomas
Pauliina Homsy1, Ilkka Heiskanen2, Mika Sampo3
1Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Finland, Helsinki, Finland.
Journal of Surgical Oncology
|July 16, 2020
Summary
Retroperitoneal liposarcomas frequently recur locally but rarely metastasize. Histological type and grade are key predictors of survival after resection, especially with clear margins.
Area of Science:
- Oncology
- Surgical Pathology
- Soft Tissue Sarcomas
Background:
- Retroperitoneal liposarcomas are the most common retroperitoneal soft tissue sarcomas.
- Radical excision is challenging due to tumor size and proximity to vital structures.
Purpose of the Study:
- To present a 30-year experience in treating retroperitoneal liposarcomas.
- To analyze factors influencing patient survival.
Main Methods:
- Retrospective review of 107 patients treated between 1987-2017.
- Kaplan-Meier analysis for survival outcomes.
- Cox regression for factor analysis.
Main Results:
- 5-year disease-specific survival was 66%.
- Local recurrence occurred in 72% of patients.
- Histological type, grade, and multifocality predicted survival and recurrence.
Conclusions:
- Retroperitoneal liposarcomas have a high local recurrence rate but low metastatic potential.
- Histological factors are significant predictors of survival in resected tumors.
