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Quantitation of residual valproic acid in flu vaccine drug substance

Gengcheng Yang1, Xiangchun Wang1, Yanhong Yang1

  • 1Vaccine Production Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Gaithersburg, MD, United States.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|July 16, 2020
PubMed

Keywords:
Biopharmaceutical manufacturingCell transfectionDerivatizationDrug SubstanceHPLCLiquid phase extractionSalting-outVaccineValproic acid

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Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
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