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Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer

Jun Sheng Wong1,2, Yoke Kqueen Cheah1

  • 1Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia.

Non-Coding RNA
|July 17, 2020
PubMed

Insights

MicroRNAs (miRNAs) regulate genes critical for cell function. Aberrant miRNA expression drives breast cancer progression, impacting survival and treatment resistance, highlighting their therapeutic potential.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Aberrant miRNA expression is linked to cancer progression, including cell proliferation, apoptosis, metastasis, and chemoresistance.
  • Dysregulated signaling pathways are a hallmark of malignancies driven by altered miRNA levels.

Purpose of the Study:

  • To review miRNA biogenesis pathways and research models.
  • To summarize recent findings on miRNA roles in breast cancer.
  • To discuss potential miRNA-based therapeutic strategies for breast cancer.

Main Methods:

  • Literature review of miRNA biogenesis and function.
  • Analysis of current research on microRNAs in breast cancer.
  • Exploration of therapeutic applications of miRNAs.

Main Results:

  • MiRNAs play crucial roles in regulating cellular processes relevant to cancer.
  • Specific miRNAs are implicated as oncogenes or tumor suppressors in breast cancer.
  • Emerging evidence supports the potential of miRNAs as therapeutic targets and agents.

Conclusions:

  • Understanding miRNA pathways is essential for cancer research.
  • MicroRNAs offer promising avenues for novel breast cancer therapies.
  • Targeting miRNAs could overcome treatment resistance and improve patient outcomes.
Keywords:
breast cancercell linemiRNA-based therapeuticsmicroRNAs

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