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[Reference ranges of platelet and related parameters within 24 hours after birth in preterm infants with different
You-Ping Wang1, Jin-Nan Feng, Zhen-Yu Li
1Department of Neonatology, Bethune First Hospital of Jilin University, Changchun 130000, China. wuhui97@126.com.
Insights
Reference ranges for platelet parameters in preterm infants vary by gestational age. Mean platelet volume (MPV) and platelet distribution width (PDW) differ significantly between preterm infant groups, aiding clinical practice.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatrics
Background:
- Platelet parameters are crucial for assessing neonatal health.
- Establishing accurate reference ranges for preterm infants is essential for timely diagnosis and treatment.
- Gestational age significantly influences physiological parameters in newborns.
Purpose of the Study:
- To determine the reference ranges for platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) in preterm infants within 24 hours of birth.
- To investigate the influence of different gestational ages on these platelet parameters.
- To provide clinically relevant reference ranges for preterm neonates.
Main Methods:
- Retrospective analysis of chart data from 1,070 preterm infants (23-36+6 weeks gestational age).
- Inclusion and exclusion criteria were applied to select eligible neonates admitted to the NICU.
- Platelet parameters were calculated within 24 hours of birth for different gestational age groups.
Main Results:
- No significant differences in PLT and PCT were observed across different gestational ages.
- Late preterm infants (34-36+6 weeks) showed significantly lower MPV and PDW compared to extremely preterm (23-27+6 weeks) and early preterm (28-33+6 weeks) infants.
- No significant sex-based differences were found in the studied platelet parameters.
Conclusions:
- MPV and PDW demonstrate significant variations among preterm infants based on gestational age within the first 24 hours post-birth.
- Developing gestational age-specific reference ranges for MPV and PDW is recommended for improved clinical utility.
- These findings support tailored hematological assessments for preterm neonates.
Objective:
To study the reference ranges of platelet and related parameters within 24 hours after birth in preterm infants with different gestational ages.
Methods:
According to the inclusion and exclusion criteria, a retrospective analysis was performed for the chart review data of 1 070 preterm infants with a gestational age of 23-36+6 weeks who were admitted to the neonatal intensive care unit from January to December in 2018. The reference ranges of platelet parameters were calculated for the preterm infants within 24 hours after birth.
Results:
There were no significant differences in platelet count (PLT) and plateletcrit (PCT) among the preterm infants with different gestational ages (P>0.05). The late preterm infants (34-36+6 weeks; n=667) had significantly lower mean platelet volume (MPV) and platelet distribution width (PDW) than the extremely preterm infants (23-27+6 weeks; n=36) and the early preterm infants (28-33+6 weeks; n=367) (P<0.05). There were no significant differences in these platelet parameters between the preterm infants with different sexes (P>0.05). The reference ranges of platelet parameters in preterm infants were calculated based on gestational age. The reference ranges of PLT and PCT were (92-376)×109/L and 0.1%-0.394% respectively, for the preterm infants with a gestational age of 23-36+6 weeks. The reference ranges of MPV and PDW were 9.208-12.172 fl and 8.390%-16.407% respectively, for the preterm infants with a gestational age of 23-36+6 weeks; the reference ranges of MPV and PDW were 9.19-11.95 fl and 9.046%-15.116% respectively, for the preterm infants with a gestational age of 34-36+6 weeks.
Conclusions:
The MPV and PDW of preterm infants with different gestational age are different within 24 hours after birth, and it is more helpful for clinical practice to formulate the reference range of MPV and PDW according to gestational age.
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