Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes

Area of Science:

• Ophthalmology
• Vision Science

Background:

• Geographic atrophy (GA) is a leading cause of irreversible vision loss.
• Comprehensive evaluation of visual function in GA is crucial for understanding its impact.

Purpose of the Study:

• To compare visual function in eyes with GA versus normal eyes.
• To assess the relationship between visual function and quality of life in GA patients.

Main Methods:

• Observational study of 63 patients (32 with GA, 31 normal).
• Assessed visual acuity (BCVA, LLVA), reading speed, microperimetry, fixation stability, contrast sensitivity (CSF).
• Evaluated anatomy with SD-OCT and FAF; quality of life with NEI VFQ-25.

Main Results:

• GA eyes showed reduced visual function and quality of life.
• Strong correlations found between reading speed, CSF, macular sensitivity, and NEI VFQ-25 composite score in GA patients.
• Atrophic area negatively correlated with quality of life.

Conclusions:

• Decreased visual function in GA leads to a poorer quality of life.
• Reading speed, contrast sensitivity, fixation, and macular sensitivity are vital indicators.
• Microperimetry and reading speed are valuable tools for assessing visual impairment in GA.